| 28-05 | 23:00 | LDU Quito |  | vs |  | Universitario | Grp.D | 1.46 | 4.55 | 7.28 | h2h |
| 28-05 | 23:00 | Peñarol |  | vs |  | Rosario Central | Grp.G | 2.04 | 3.38 | 4.03 |  |
| 28-05 | 23:00 | Junior Barranquilla |  | vs |  | Botafogo | Grp.D | 2.80 | 3.34 | 2.61 | h2h |
| 28-05 | 23:00 | Atlético Mineiro |  | vs |  | Caracas FC | Grp.G | 1.08 | 12.40 | 29.50 | h2h |
| 29-05 | 01:00 | Bolívar |  | vs |  | Palestino | Grp.E | 1.26 | 6.33 | 11.50 | h2h |
| 29-05 | 01:00 | Flamengo |  | vs |  | Millonarios | Grp.E | 1.14 | 8.50 | 20.50 | h2h |
| 27-05 | 19:00 | Al Nassr |  | 4-2 |  | Al-Ittihad Jeddah | D34 |
