| 16-05 | 18:30 | Las Palmas |  | 2-2 |  | Real Betis | D36 | ||||
| 16-05 | 20:30 | Almería |  | 0-2 |  | Barcelona | D36 | ||||
| 16-05 | 21:00 | Real Sociedad |  | 1-0 |  | Valencia | D36 |
| 16-05 | 23:00 | Rosario Central |  | 4-1 |  | Caracas FC | Grp.G | ||||
| 17-05 | 01:00 | San Lorenzo |  | 3-2 |  | Liverpool Montevideo | Grp.F | ||||
| 16-05 | 23:00 | Universitario |  | 0-1 |  | Botafogo | Grp.D | ||||
| 16-05 | 23:00 | Fluminense |  | 2-1 |  | Cerro Porteño | Grp.A | ||||
| 17-05 | 01:00 | São Paulo |  | 0-0 |  | Barcelona SC | Grp.B |
| 17-05 | 19:00 | Al Nassr |  | vs |  | Al Hilal | D32 | 3.33 | 3.92 | 1.91 | h2h |
| 17-05 | 19:45 | Fiorentina |  | vs |  | Napoli | D37 | 2.45 | 3.48 | 3.21 | h2h |
